Activated Ras has been shown to provide powerful antiapoptotic signals to cells through
well defined transcriptional and post-translational pathways, whereas translational control
as a mechanism of Ras survival signaling remains unexplored. Here we show a direct
relationship between assembly of the cap-dependent translation initiation apparatus and
suppression of apoptosis by oncogenic Ras in vitro and in vivo. Decreasing protein
synthesis with rapamycin, which is known to inhibit cap-dependent translation, increases the …