Cytostatic mechanism and antitumor potential of novel 1H-cyclopenta [b] benzofuran lignans isolated from Aglaiaelliptica
SK Lee, B Cui, RR Mehta, AD Kinghorn… - Chemico-biological …, 1998 - Elsevier
A total of five 1H-cyclopenta [b] benzofuran lignans (1–5) isolated from the stems of
Aglaiaelliptica Bl.(Meliaceae) inhibited the growth of human cancer cells in culture. Of
particular note, the IC50 values observed with 1 (methyl rocaglate), 2 (4′-demethoxy-3′,
4′-methylenedioxy-methyl rocaglate) and 5 (1-O-formyl-4′-demethoxy-3′, 4′-
methylenedioxy-methyl rocaglate) were in the 1–30 ng/ml range. Prompted by the high
potency of these responses, additional studies were performed with 2, a structurally …
Aglaiaelliptica Bl.(Meliaceae) inhibited the growth of human cancer cells in culture. Of
particular note, the IC50 values observed with 1 (methyl rocaglate), 2 (4′-demethoxy-3′,
4′-methylenedioxy-methyl rocaglate) and 5 (1-O-formyl-4′-demethoxy-3′, 4′-
methylenedioxy-methyl rocaglate) were in the 1–30 ng/ml range. Prompted by the high
potency of these responses, additional studies were performed with 2, a structurally …