[58] Animal models of chronic ethanol toxicity

CS Lieber, LM Decarli - Methods in enzymology, 1994 - Elsevier
Publisher Summary This chapter introduces an experimental model for the toxic effect
created by overcoming the natural aversion of the rodent for alcohol by incorporating the
ethanol in a totally liquid diet. This technique provides flexibility to adjust to special
experimental or physiological needs by allowing for various substitutions, including changes
in lipids, proteins, or other dietary constituents. This procedure is thereby ideally suited for
the study of the interactions of alcohol with deficiency or excess of various nutrients. The …