Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia
J Zheng, MR Thylin, A Ghorpade, H Xiong… - Journal of …, 1999 - Elsevier
The mechanism (s) by which HIV-1 affects neural injury in HIV-1-associated dementia (HAD)
remains unknown. To ascertain the role that cellular and viral macrophage products play in
HAD neurotoxicity, we explored one potential route for neuronal demise, CXCR4. CXCR4,
expressed on lymphocytes and neurons, is both a part of neural development and a co-
receptor for HIV-1. Its ligand, stromal cell-derived factor-1α (SDF-1α), affects neuronal
viability. GTP binding protein (G-protein) linked signaling after neuronal exposure to SDF …
remains unknown. To ascertain the role that cellular and viral macrophage products play in
HAD neurotoxicity, we explored one potential route for neuronal demise, CXCR4. CXCR4,
expressed on lymphocytes and neurons, is both a part of neural development and a co-
receptor for HIV-1. Its ligand, stromal cell-derived factor-1α (SDF-1α), affects neuronal
viability. GTP binding protein (G-protein) linked signaling after neuronal exposure to SDF …