[HTML][HTML] HIP1 and HIP12 display differential binding to F-actin, AP2, and clathrin: Identification of a novel interaction with clathrin light chain
V Legendre-Guillemin, M Metzler… - Journal of Biological …, 2002 - ASBMB
Huntingtin-interacting protein 1 (HIP1) and HIP12 are orthologues of Sla2p, a yeast protein
with essential functions in endocytosis and regulation of the actin cytoskeleton. We now
report that HIP1 and HIP12 are major components of the clathrin coat that interact but differ
in their ability to bind clathrin and the clathrin adaptor AP2. HIP1 contains a clathrin-box and
AP2 consensus-binding sites that display high affinity binding to the terminal domain of the
clathrin heavy chain and the ear domain of the AP2 α subunit, respectively. These …
with essential functions in endocytosis and regulation of the actin cytoskeleton. We now
report that HIP1 and HIP12 are major components of the clathrin coat that interact but differ
in their ability to bind clathrin and the clathrin adaptor AP2. HIP1 contains a clathrin-box and
AP2 consensus-binding sites that display high affinity binding to the terminal domain of the
clathrin heavy chain and the ear domain of the AP2 α subunit, respectively. These …