[HTML][HTML] Gastrin-induced apoptosis contributes to carcinogenesis in the stomach
G Cui, S Takaishi, W Ai, KS Betz, J Florholmen… - Laboratory …, 2006 - Elsevier
Hypergastrinemia in INS-GAS mice leads to accelerated carcinogenesis of the stomach, but
the mechanisms have not been well defined. We investigated the possible role of gastrin-
induced gastric cell apoptosis in the development of gastric cancer. We examined apoptosis
and the expression of Bcl-2 family proteins in INS-GAS mice of different ages, as well as in
gastrin-deficient (GAS-KO) mice after gastrin-17 (G-17) infusion. In addition, we studied the
effects of the gastrin/cholecystokinin-2 (CCK-2) receptor antagonist YF476 and/or histamine …
the mechanisms have not been well defined. We investigated the possible role of gastrin-
induced gastric cell apoptosis in the development of gastric cancer. We examined apoptosis
and the expression of Bcl-2 family proteins in INS-GAS mice of different ages, as well as in
gastrin-deficient (GAS-KO) mice after gastrin-17 (G-17) infusion. In addition, we studied the
effects of the gastrin/cholecystokinin-2 (CCK-2) receptor antagonist YF476 and/or histamine …