Mice provide an experimental model of unparalleled flexibility for studying mammalian
diseases. Inbred strains of mice exhibit substantial differences in their susceptibility to the
renal complications of diabetes. Much remains to be established regarding the course of
diabetic nephropathy (DN) in mice as well as defining those strains and/or mutants that are
most susceptible to renal injury from diabetes. Through the use of the unique genetic
reagents available in mice (including knockouts and transgenics), the validation of a mouse …