Immunocytochemical localization of distinct isoforms of nitric oxide synthase in the juxtaglomerular apparatus of normal rat kidney.
A Tojo, SS Gross, L Zhang, CC Tisher… - Journal of the …, 1994 - journals.lww.com
Nitric oxide (NO) is a messenger molecule that functions as a vasodilator and accounts for
the biologic activity of endothelium-derived relaxing factor (EDRF). The enzyme responsible
for NO production, NO synthase (NOS), exists in different isoforms. Some are expressed
constitutively in various tissues, whereas others require induction by endotoxin and
cytokines. There is evidence that NO plays an important role in the regulation of basal renal
vascular resistance and in the tubuloglomerular feedback response. Specific antibodies to a …
the biologic activity of endothelium-derived relaxing factor (EDRF). The enzyme responsible
for NO production, NO synthase (NOS), exists in different isoforms. Some are expressed
constitutively in various tissues, whereas others require induction by endotoxin and
cytokines. There is evidence that NO plays an important role in the regulation of basal renal
vascular resistance and in the tubuloglomerular feedback response. Specific antibodies to a …