AKT1 is associated with schizophrenia across multiple symptom dimensions in the Irish study of high density schizophrenia families
BACKGROUND: The phosphatidylinositol 3-kinase (PI3K)-AKT signal transduction pathway
is critical to cell growth and survival. In vitro functional studies indicate that the candidate
schizophrenia susceptibility gene DTNBP1 influences AKT signaling to promote neuronal
viability. The AKT1 gene has also been implicated in schizophrenia by association studies
and decreased protein expression in the brains of schizophrenic patients. METHODS: The
association of DTNBP1 in the Irish Study of High Density Schizophrenia Families (ISHDSF) …
is critical to cell growth and survival. In vitro functional studies indicate that the candidate
schizophrenia susceptibility gene DTNBP1 influences AKT signaling to promote neuronal
viability. The AKT1 gene has also been implicated in schizophrenia by association studies
and decreased protein expression in the brains of schizophrenic patients. METHODS: The
association of DTNBP1 in the Irish Study of High Density Schizophrenia Families (ISHDSF) …