[HTML][HTML] Removal of FKBP12. 6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular …
J Xiao, X Tian, PP Jones, J Bolstad, H Kong… - Journal of biological …, 2007 - ASBMB
The 12.6-kDa FK506-binding protein (FKBP12. 6) is considered to be a key regulator of the
cardiac ryanodine receptor (RyR2), but its precise role in RyR2 function is complex and
controversial. In the present study we investigated the impact of FKBP12. 6 removal on the
properties of the RyR2 channel and the propensity for spontaneous Ca 2+ release and the
occurrence of ventricular arrhythmias. Single channel recordings in lipid bilayers showed
that FK506 treatment of recombinant RyR2 co-expressed with or without FKBP12. 6 or native …
cardiac ryanodine receptor (RyR2), but its precise role in RyR2 function is complex and
controversial. In the present study we investigated the impact of FKBP12. 6 removal on the
properties of the RyR2 channel and the propensity for spontaneous Ca 2+ release and the
occurrence of ventricular arrhythmias. Single channel recordings in lipid bilayers showed
that FK506 treatment of recombinant RyR2 co-expressed with or without FKBP12. 6 or native …