Antipsychotics alter the protein expression levels of β-catenin and GSK-3 in the rat medial prefrontal cortex and striatum

H Alimohamad, N Rajakumar, YH Seah, W Rushlow - Biological psychiatry, 2005 - Elsevier
BACKGROUND: It has been demonstrated that schizophrenics have altered levels and/or
phosphorylation states of several Wnt related proteins in the brain, including β-catenin and
GSK-3, and may represent susceptibility loci for schizophrenia. The current study was
conducted to assess the effects of antipsychotics on β-catenin and glycogen synthase
kinase-3. METHODS: Western blotting and immunocytochemistry were employed to
investigate the effects of antipsychotics on β-catenin and glycogen synthase kinase-3 …