Induction of CD8+ T cell responses through targeting of antigen to Dectin-2
RW Carter, C Thompson, DM Reid, SYC Wong… - Cellular …, 2006 - Elsevier
Targeted delivery of antigens to dendritic cells (DC) can be used to optimise immunisation.
We investigated whether the efficacy with which immune responses are induced can be
improved by targeting Ags to a C-type lectin receptor, Dectin-2. When anti-Dectin-2 mAbs
were injected sc, mAb binding was detected on a low percentage of DC in the draining
lymph node. Ag conjugated to anti-Dectin-2 mAbs was presented efficiently to CD8+ T cells
in vivo and elicited CD8+ T cell responses at low doses where free Ag failed to induce a …
We investigated whether the efficacy with which immune responses are induced can be
improved by targeting Ags to a C-type lectin receptor, Dectin-2. When anti-Dectin-2 mAbs
were injected sc, mAb binding was detected on a low percentage of DC in the draining
lymph node. Ag conjugated to anti-Dectin-2 mAbs was presented efficiently to CD8+ T cells
in vivo and elicited CD8+ T cell responses at low doses where free Ag failed to induce a …