[HTML][HTML] Presenilin/γ-secretase-mediated cleavage of the voltage-gated sodium channel β2-subunit regulates cell adhesion and migration
DY Kim, LAMK Ingano, BW Carey, WH Pettingell… - Journal of Biological …, 2005 - ASBMB
The voltage-gated sodium channel β2-subunit (β2) is a member of the IgCAM superfamily
and serves as both an adhesion molecule and an auxiliary subunit of the voltage-gated
sodium channel. Here we found that β2 undergoes ectodomain shedding followed by
presenilin (PS)-dependent γ-secretase-mediated cleavage. 12-O-Tetradecanoylphorbol-13-
acetate treatment or expression of an α-secretase enzyme, ADAM10, resulted in ectodomain
cleavage of β2 in Chinese hamster ovary cells. Subsequent cleavage of the remaining 15 …
and serves as both an adhesion molecule and an auxiliary subunit of the voltage-gated
sodium channel. Here we found that β2 undergoes ectodomain shedding followed by
presenilin (PS)-dependent γ-secretase-mediated cleavage. 12-O-Tetradecanoylphorbol-13-
acetate treatment or expression of an α-secretase enzyme, ADAM10, resulted in ectodomain
cleavage of β2 in Chinese hamster ovary cells. Subsequent cleavage of the remaining 15 …