[HTML][HTML] Cloning, localization, and functional expression of sodium channel β1A subunits

KA Kazen-Gillespie, DS Ragsdale, MR D'Andrea… - Journal of Biological …, 2000 - ASBMB
Auxiliary β1 subunits of voltage-gated sodium channels have been shown to be cell
adhesion molecules of the Ig superfamily. Co-expression of α and β1 subunits modulates
channel gating as well as plasma membrane expression levels. We have cloned,
sequenced, and expressed a splice variant of β1, termed β1A, that results from an apparent
intron retention event. β1 and β1A are structurally homologous proteins with type I
membrane topology; however, they contain little to no amino acid homology beyond the …