Pax3: a paired domain gene as a regulator in PNS myelination
Pax3 RNA is expressed in neural crest when Schwann cell (SC) precursors migrate to the
PNS, Pax3 RNA and SC markers were monitored in sciatic nerves of mice during
development and nerve repair. An inverse correlation was observed between expression of
Pax3 RNA and myelin basic protein (MBP). inverse correlation was also observed in SC
primary cultures. Treating cultures with forskolin, an adenylate cyclase agonist, repressed
Pax3 RNA, GFAP, NGFR, N-CAM, and L1 and elevated MBP. Subsequent microinjection …
PNS, Pax3 RNA and SC markers were monitored in sciatic nerves of mice during
development and nerve repair. An inverse correlation was observed between expression of
Pax3 RNA and myelin basic protein (MBP). inverse correlation was also observed in SC
primary cultures. Treating cultures with forskolin, an adenylate cyclase agonist, repressed
Pax3 RNA, GFAP, NGFR, N-CAM, and L1 and elevated MBP. Subsequent microinjection …
Summary
Pax3 RNA is expressed in neural crest when Schwann cell (SC) precursors migrate to the PNS, Pax3 RNA and SC markers were monitored in sciatic nerves of mice during development and nerve repair. An inverse correlation was observed between expression of Pax3 RNA and myelin basic protein (MBP). inverse correlation was also observed in SC primary cultures. Treating cultures with forskolin, an adenylate cyclase agonist, repressed Pax3 RNA, GFAP, NGFR, N-CAM, and L1 and elevated MBP. Subsequent microinjection with
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