B cell development and its deregulation to transformed states at the pre-B cell receptor-expressing pre-BII cell stage
F Melchers - Chronic Lymphocytic Leukemia, 2005 - Springer
F Melchers
Chronic Lymphocytic Leukemia, 2005•SpringerThis chapter will review the scenario of normal B cell development—from the decision of a
lymphoid progenitor to enter the B-lineage, over the stages of the generation of the
repertoires of antigen-receptor (immunoglobulin)-expressing cells, to the response of mature
B cells to develop memory and plasma cells—highlighting some of the cellular stages and
the molecular mechanisms that can generate and select transformed states of cells. The
scenarios for pre-B lymphoma (lymphocytic leukaemia) development are discussed in more …
lymphoid progenitor to enter the B-lineage, over the stages of the generation of the
repertoires of antigen-receptor (immunoglobulin)-expressing cells, to the response of mature
B cells to develop memory and plasma cells—highlighting some of the cellular stages and
the molecular mechanisms that can generate and select transformed states of cells. The
scenarios for pre-B lymphoma (lymphocytic leukaemia) development are discussed in more …
Abstract
This chapter will review the scenario of normal B cell development—from the decision of a lymphoid progenitor to enter the B-lineage, over the stages of the generation of the repertoires of antigen-receptor (immunoglobulin)-expressing cells, to the response of mature B cells to develop memory and plasma cells—highlighting some of the cellular stages and the molecular mechanisms that can generate and select transformed states of cells. The scenarios for pre-B lymphoma (lymphocytic leukaemia) development are discussed in more detail.
Springer