Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: its occurrence and role
M Wheatley, SR Hawtin - Human reproduction update, 1999 - academic.oup.com
M Wheatley, SR Hawtin
Human reproduction update, 1999•academic.oup.comMany hormones that are central to normal reproductive functioning mediate their
physiological effects by activating a receptor which belongs to the large family of G-protein-
coupled receptors (GPCR). Members of this family of receptor proteins are usually
glycosylated on extracellular domains. In recent years the role of this glycosylation in cells
surface expression/protein folding, ligand recognition and receptor-effector coupling has
been investigated. This review summarises current knowledge of the role of glycosylation in …
physiological effects by activating a receptor which belongs to the large family of G-protein-
coupled receptors (GPCR). Members of this family of receptor proteins are usually
glycosylated on extracellular domains. In recent years the role of this glycosylation in cells
surface expression/protein folding, ligand recognition and receptor-effector coupling has
been investigated. This review summarises current knowledge of the role of glycosylation in …
Abstract
Many hormones that are central to normal reproductive functioning mediate their physiological effects by activating a receptor which belongs to the large family of G-protein-coupled receptors (GPCR). Members of this family of receptor proteins are usually glycosylated on extracellular domains. In recent years the role of this glycosylation in cells surface expression/protein folding, ligand recognition and receptor-effector coupling has been investigated. This review summarises current knowledge of the role of glycosylation in the functioning of the receptors for gonadotrophin-releasing hormone (GnRH), luteinizing hormone/human chorionic gonadotrophin (LH/HCG), follicle stimulating hormone (FSH), oxytocin (OT) and vasopressin (AVP).
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