[HTML][HTML] Regulation of angiotensin II type 1A receptor intracellular retention, degradation, and recycling by Rab5, Rab7, and Rab11 GTPases
LB Dale, JL Seachrist, AV Babwah… - Journal of Biological …, 2004 - ASBMB
Previous studies have demonstrated that the interaction of the angiotensin II type 1A
receptor (AT 1A R) carboxyl-terminal tail with Rab5a may modulate Rab5a activity, leading
to the homotypic fusion of endocytic vesicles. Therefore, we have investigated whether AT
1A R/Rab5a interactions mediate the retention of AT 1A R· β-arrestin complexes in early
endosomes and whether the overexpression of Rab7 and Rab11 GTPases influences AT 1A
R lysosomal degradation and plasma membrane recycling. We found that internalized AT …
receptor (AT 1A R) carboxyl-terminal tail with Rab5a may modulate Rab5a activity, leading
to the homotypic fusion of endocytic vesicles. Therefore, we have investigated whether AT
1A R/Rab5a interactions mediate the retention of AT 1A R· β-arrestin complexes in early
endosomes and whether the overexpression of Rab7 and Rab11 GTPases influences AT 1A
R lysosomal degradation and plasma membrane recycling. We found that internalized AT …