Protein conformation disorders or proteinopathies are a growing family of human diseases
that are characterized by the accumulation of proteins in intracellular aggregates (also
known as inclusions) in specific tissues/organs. The role of aggregates in these diseases
has been a subject of vigorous debate. However, irrespective of the nature (s) of the toxic
species, it is desirable for cells to be able to control the levels of these toxic proteins and
restrict their accumulation. Here we discuss how the autophagy-lysosome pathway may …