[HTML][HTML] Insights into the structural basis of the GADD45β-mediated inactivation of the JNK kinase, MKK7/JNKK2
NF-κB/Rel factors control programmed cell death (PCD), and this control is crucial to
oncogenesis, cancer chemoresistance, and antagonism of tumor necrosis factor (TNF) α-
induced killing. With TNFα, NF-κB-mediated protection involves suppression of the c-Jun-N-
terminal kinase (JNK) cascade, and we have identified Gadd45β, a member of the Gadd45
family, as a pivotal effector of this activity of NF-κB. Inhibition of TNFα-induced JNK signaling
by Gadd45β depends on direct targeting of the JNK kinase, MKK7/JNKK2. The mechanism …
oncogenesis, cancer chemoresistance, and antagonism of tumor necrosis factor (TNF) α-
induced killing. With TNFα, NF-κB-mediated protection involves suppression of the c-Jun-N-
terminal kinase (JNK) cascade, and we have identified Gadd45β, a member of the Gadd45
family, as a pivotal effector of this activity of NF-κB. Inhibition of TNFα-induced JNK signaling
by Gadd45β depends on direct targeting of the JNK kinase, MKK7/JNKK2. The mechanism …