[HTML][HTML] The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation
This review outlines the mechanisms underlying the interaction between the nervous and
immune systems of the host in response to an immune challenge. The main focus is the
cholinergic anti-inflammatory pathway, which we recently described as a novel function of
the efferent vagus nerve. This pathway plays a critical role in controlling the inflammatory
response through interaction with peripheral α7 subunit-containing nicotinic acetylcholine
receptors expressed on macrophages. We describe the modulation of systemic and local …
immune systems of the host in response to an immune challenge. The main focus is the
cholinergic anti-inflammatory pathway, which we recently described as a novel function of
the efferent vagus nerve. This pathway plays a critical role in controlling the inflammatory
response through interaction with peripheral α7 subunit-containing nicotinic acetylcholine
receptors expressed on macrophages. We describe the modulation of systemic and local …
Abstract
This review outlines the mechanisms underlying the interaction between the nervous and immune systems of the host in response to an immune challenge. The main focus is the cholinergic anti-inflammatory pathway, which we recently described as a novel function of the efferent vagus nerve. This pathway plays a critical role in controlling the inflammatory response through interaction with peripheral α7 subunit-containing nicotinic acetylcholine receptors expressed on macrophages. We describe the modulation of systemic and local inflammation by the cholinergic anti-inflammatory pathway and its function as an interface between the brain and the immune system. The clinical implications of this novel mechanism also are discussed.
Springer