Loss of the VEGF164 and VEGF188 isoforms impairs postnatal glomerular angiogenesis and renal arteriogenesis in mice
V Mattot, L Moons, F Lupu, D Chernavvsky… - Journal of the …, 2002 - journals.lww.com
Vascular endothelial growth factor (VEGF) is transcribed in the VEGF 120, VEGF 164, or
VEGF 188 isoforms, which differ in receptor binding, matrix association, and angiogenic
activity. This vascular growth factor has been implicated in the development of the renal
vasculature, but the role of the distinct VEGF isoforms remains unknown. In the present
report, renal angiogenesis and arteriogenesis were studied in VEGF 120/120 mice,
expressing only the short VEGF 120 isoform. In VEGF 120/120 mice, ingrowth and survival …
VEGF 188 isoforms, which differ in receptor binding, matrix association, and angiogenic
activity. This vascular growth factor has been implicated in the development of the renal
vasculature, but the role of the distinct VEGF isoforms remains unknown. In the present
report, renal angiogenesis and arteriogenesis were studied in VEGF 120/120 mice,
expressing only the short VEGF 120 isoform. In VEGF 120/120 mice, ingrowth and survival …