[HTML][HTML] Induction of leptin receptor expression in the liver by leptin and food deprivation
P Cohen, G Yang, X Yu, AA Soukas, CS Wolfish… - Journal of Biological …, 2005 - ASBMB
Leptin resistance is a common feature of obesity and the metabolic syndrome. However, the
regulated expression of the leptin receptor (Ob-R) has not been studied in detail. Expression
profiling of liver mRNA in leptin-treated wild-type mice revealed a marked increase in leptin
receptor mRNA levels, which had not previously been described. This was confirmed by
isoform-specific real-time PCR, which showed a> 25-fold increase in the mRNAs encoding
the short forms (Ob-Ra, Ob-Rc) and a> 10-fold increase in the mRNA encoding the long (Ob …
regulated expression of the leptin receptor (Ob-R) has not been studied in detail. Expression
profiling of liver mRNA in leptin-treated wild-type mice revealed a marked increase in leptin
receptor mRNA levels, which had not previously been described. This was confirmed by
isoform-specific real-time PCR, which showed a> 25-fold increase in the mRNAs encoding
the short forms (Ob-Ra, Ob-Rc) and a> 10-fold increase in the mRNA encoding the long (Ob …