[HTML][HTML] Deficient tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor transport to the cell surface in human colon cancer cells selected for …
Z Jin, ER McDonald, DT Dicker, WS El-Deiry - Journal of Biological …, 2004 - ASBMB
Many tumor cell types are sensitive to tumor necrosis factor-related apoptosis-inducing
ligand (TRAIL)-induced apoptosis. Incubation of TRAIL-sensitive cells with TRAIL invariably
leads to resistant survivors even when high doses of TRAIL are used. Because the
emergence of resistance to apoptosis is a major concern in successful treatment of cancer,
and TRAIL survivors may contribute to therapeutic failure, we investigated potential
resistance mechanisms. We selected TRAIL-resistant SW480 human colon adenocarcinoma …
ligand (TRAIL)-induced apoptosis. Incubation of TRAIL-sensitive cells with TRAIL invariably
leads to resistant survivors even when high doses of TRAIL are used. Because the
emergence of resistance to apoptosis is a major concern in successful treatment of cancer,
and TRAIL survivors may contribute to therapeutic failure, we investigated potential
resistance mechanisms. We selected TRAIL-resistant SW480 human colon adenocarcinoma …