Apoptosis in the treatment of cancer: a promise kept?
XW Meng, SH Lee, SH Kaufmann - Current opinion in cell biology, 2006 - Elsevier
XW Meng, SH Lee, SH Kaufmann
Current opinion in cell biology, 2006•ElsevierA common feature of cancer cells is their ability to evade apoptosis as a result of alterations
that block cell death signaling pathways. The extensive research efforts that elucidated
these signaling pathways over the past decade have set the stage for the development of
therapeutic agents that either kill cancer cells selectively or reset their apoptotic threshold.
Over the past two years a number of these agents have been evaluated in preclinical and
clinical trials. The results of these studies suggest that it might soon be possible to modulate …
that block cell death signaling pathways. The extensive research efforts that elucidated
these signaling pathways over the past decade have set the stage for the development of
therapeutic agents that either kill cancer cells selectively or reset their apoptotic threshold.
Over the past two years a number of these agents have been evaluated in preclinical and
clinical trials. The results of these studies suggest that it might soon be possible to modulate …
A common feature of cancer cells is their ability to evade apoptosis as a result of alterations that block cell death signaling pathways. The extensive research efforts that elucidated these signaling pathways over the past decade have set the stage for the development of therapeutic agents that either kill cancer cells selectively or reset their apoptotic threshold. Over the past two years a number of these agents have been evaluated in preclinical and clinical trials. The results of these studies suggest that it might soon be possible to modulate apoptosis in cancer cells for therapeutic benefit.
Elsevier