Publisher Summary The cells of solid tumors, in contrast to those of leukemia, exist for most
of their life-span outside the blood stream or bone marrow. Such tumor cells grow in densely
packed populations that develop into spheroid or ellipsoid aggregates. Neovascularization
is an event that separates the development of any solid tumor into two stages: the avascular
stage and the vascular stage. Because of this angiogenesis plays a critical role in the
biology of solid neoplasms. The two stages can be dissociated under experimental …