Cancer's molecular sweet tooth and the Warburg effect
More than 80 years ago, the renowned biochemist Otto Warburg described how cancer cells
avidly consume glucose and produce lactic acid under aerobic conditions. Recent studies
arguing that cancer cells benefit from this phenomenon, termed the Warburg effect, have
renewed discussions about its exact role as cause, correlate, or facilitator of cancer.
Molecular advances in this area may reveal tactics to exploit the cancer cell's “sweet tooth”
for cancer therapy.(Cancer Res 2006; 66 (18): 8927-30)
avidly consume glucose and produce lactic acid under aerobic conditions. Recent studies
arguing that cancer cells benefit from this phenomenon, termed the Warburg effect, have
renewed discussions about its exact role as cause, correlate, or facilitator of cancer.
Molecular advances in this area may reveal tactics to exploit the cancer cell's “sweet tooth”
for cancer therapy.(Cancer Res 2006; 66 (18): 8927-30)
Abstract
More than 80 years ago, the renowned biochemist Otto Warburg described how cancer cells avidly consume glucose and produce lactic acid under aerobic conditions. Recent studies arguing that cancer cells benefit from this phenomenon, termed the Warburg effect, have renewed discussions about its exact role as cause, correlate, or facilitator of cancer. Molecular advances in this area may reveal tactics to exploit the cancer cell's “sweet tooth” for cancer therapy. (Cancer Res 2006; 66(18): 8927-30)
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