[HTML][HTML] Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner
H Akiyoshi, S Hatakeyama, J Pitkänen, Y Mouri… - Journal of Biological …, 2004 - ASBMB
Autoimmune regulator (AIRE) is responsible for the development of organ-specific
autoimmune disease in a monogenic fashion. Rare and low levels of tissue expression
together with the lack of AIRE-expressing cell lines have hampered a detailed analysis of
the molecular dynamics of AIRE. Here we have established cell lines stably transfected with
AIRE and studied the regulatory mechanisms for its subcellular expression. We found that
nuclear body (NB) formation by AIRE was dependent on the cell cycle. Biochemical …
autoimmune disease in a monogenic fashion. Rare and low levels of tissue expression
together with the lack of AIRE-expressing cell lines have hampered a detailed analysis of
the molecular dynamics of AIRE. Here we have established cell lines stably transfected with
AIRE and studied the regulatory mechanisms for its subcellular expression. We found that
nuclear body (NB) formation by AIRE was dependent on the cell cycle. Biochemical …