[HTML][HTML] Shedding of kidney injury molecule-1, a putative adhesion protein involved in renal regeneration
V Bailly, Z Zhang, W Meier, R Cate, M Sanicola… - Journal of Biological …, 2002 - ASBMB
KIM-1 (kidney injury molecule-1) is a type I transmembrane glycoprotein expressed on
dedifferentiated renal proximal tubule epithelial cells undergoing regeneration after toxic or
ischemic injury. The extracellular domain of KIM-1 is composed of an immunoglobulin-like
domain topping a long mucin-like domain, a structure that points to a possible role in cell
adhesion by homology to several known adhesion proteins. Two splice variants (a and b), of
the human KIM-1 having identical extracellular domains, differ in their cytoplasmic domains …
dedifferentiated renal proximal tubule epithelial cells undergoing regeneration after toxic or
ischemic injury. The extracellular domain of KIM-1 is composed of an immunoglobulin-like
domain topping a long mucin-like domain, a structure that points to a possible role in cell
adhesion by homology to several known adhesion proteins. Two splice variants (a and b), of
the human KIM-1 having identical extracellular domains, differ in their cytoplasmic domains …