[HTML][HTML] NF-κB p50 and p52 regulate receptor activator of NF-κB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c …
Postmenopausal osteoporosis and rheumatoid joint destruction result from increased
osteoclast formation and bone resorption induced by receptor activator of NF-κB ligand
(RANKL) and tumor necrosis factor (TNF). Osteoclast formation induced by these cytokines
requires NF-κB p50 and p52, c-Fos, and NFATc1 expression in osteoclast precursors. c-Fos
induces NFATc1, but the relationship between NF-κB and these other transcription factors in
osteoclastogenesis remains poorly understood. We report that RANKL and TNF can induce …
osteoclast formation and bone resorption induced by receptor activator of NF-κB ligand
(RANKL) and tumor necrosis factor (TNF). Osteoclast formation induced by these cytokines
requires NF-κB p50 and p52, c-Fos, and NFATc1 expression in osteoclast precursors. c-Fos
induces NFATc1, but the relationship between NF-κB and these other transcription factors in
osteoclastogenesis remains poorly understood. We report that RANKL and TNF can induce …