Cytotoxic effects of kinetin riboside on mouse, human and plant tumour cells
B Griffaut, R Bos, JC Maurizis, JC Madelmont… - International journal of …, 2004 - Elsevier
B Griffaut, R Bos, JC Maurizis, JC Madelmont, G Ledoigt
International journal of biological macromolecules, 2004•ElsevierThe cytotoxicity of two plant hormone compounds, kinetin and kinetin riboside, was studied
on tumour cells, by colony forming assay with increased amount of cytotoxic molecules. The
concentration of inhibitor required to reduce cell growth to 50% was determined for these
molecules. Kinetin riboside was shown to only act on M4 Beu human and B16 murine
melanoma cells at low concentration (1.5 and 0.2 μM). On mice with leukaemia P388, this
product has no effect on the tumour growth, and it appears to be toxic at the dose of …
on tumour cells, by colony forming assay with increased amount of cytotoxic molecules. The
concentration of inhibitor required to reduce cell growth to 50% was determined for these
molecules. Kinetin riboside was shown to only act on M4 Beu human and B16 murine
melanoma cells at low concentration (1.5 and 0.2 μM). On mice with leukaemia P388, this
product has no effect on the tumour growth, and it appears to be toxic at the dose of …
The cytotoxicity of two plant hormone compounds, kinetin and kinetin riboside, was studied on tumour cells, by colony forming assay with increased amount of cytotoxic molecules. The concentration of inhibitor required to reduce cell growth to 50% was determined for these molecules. Kinetin riboside was shown to only act on M4 Beu human and B16 murine melanoma cells at low concentration (1.5 and 0.2μM). On mice with leukaemia P388, this product has no effect on the tumour growth, and it appears to be toxic at the dose of 25mg/kg. Kinetin riboside was also shown to have a cytotoxic effect on plant tumour cells (crown-gall).
Elsevier