[HTML][HTML] Cyclin D1 gene activation in human myeloma cells is independent of DNA hypomethylation or histone hyperacetylation
OBJECTIVE: Overexpression of cyclin D1 is a common event in solid and hematological
cancers. In multiple myeloma (MM), a B-cell hemopathy, one mechanism responsible for
cyclin D1 expression is the translocation t (11; 14)(q13; q32). But this translocation does not
account for cyclin D1 gene activation in all MM. We have hypothesized that epigenetic
events could regulate cyclin D1 gene transcription. METHODS: Using 6 MM cell lines
representative of different cyclin D1 expression levels and exhibiting various chromosome …
cancers. In multiple myeloma (MM), a B-cell hemopathy, one mechanism responsible for
cyclin D1 expression is the translocation t (11; 14)(q13; q32). But this translocation does not
account for cyclin D1 gene activation in all MM. We have hypothesized that epigenetic
events could regulate cyclin D1 gene transcription. METHODS: Using 6 MM cell lines
representative of different cyclin D1 expression levels and exhibiting various chromosome …