Prevalence of ras gene mutations in human colorectal cancers
JL Bos, ER Fearon, SR Hamilton, MV Vries… - Nature, 1987 - nature.com
JL Bos, ER Fearon, SR Hamilton, MV Vries, JH van Boom, AJ van der Eb, B Vogelstein
Nature, 1987•nature.comAbstract The Department of Medical Biochemistry and t Department of Organic Chemistry,
State University of Leiden, Sylvius Laboratories, The Netherlands* The Oncology Center
and t Department of Pathology, The Johns Hopkins University School of Medicine,
Baltimore, Maryland 21205, USA A combination of DNA hybridization analyses and tissue
sectioning techniques demonstrate that ras gene mutations occur in over a third of human
colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that …
State University of Leiden, Sylvius Laboratories, The Netherlands* The Oncology Center
and t Department of Pathology, The Johns Hopkins University School of Medicine,
Baltimore, Maryland 21205, USA A combination of DNA hybridization analyses and tissue
sectioning techniques demonstrate that ras gene mutations occur in over a third of human
colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that …
Abstract
The Department of Medical Biochemistry and t Department of Organic Chemistry, State University of Leiden, Sylvius Laboratories, The Netherlands * The Oncology Center and t Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA A combination of DNA hybridization analyses and tissue sectioning techniques demonstrate that ras gene mutations occur in over a third of human colorectal cancers, that most of the mutations are at codon 12 of the c-Ki-ras gene and that the mutations usually precede the development of malignancy.
nature.com