Outcome of sickle cell anemia: a 4-decade observational study of 1056 patients
DR Powars, LS Chan, A Hiti, E Ramicone, C Johnson - Medicine, 2005 - journals.lww.com
Based on a prospective cohort study of 1056 patients with sickle cell anemia (Hb SS)
initiated in 1959, we investigated the influence of calendar era, age, sex, and prior medical
conditions on the subsequent development of irreversible organ damage and survival using
the Cox regression model with time-dependent covariates adjusting for all prior occurrences.
We studied 30 acute clinical events, and focused on 8 prototypic forms of irreversible organ
damage. Childhood survival to age 20 years has improved from 79% for those born before …
initiated in 1959, we investigated the influence of calendar era, age, sex, and prior medical
conditions on the subsequent development of irreversible organ damage and survival using
the Cox regression model with time-dependent covariates adjusting for all prior occurrences.
We studied 30 acute clinical events, and focused on 8 prototypic forms of irreversible organ
damage. Childhood survival to age 20 years has improved from 79% for those born before …