[HTML][HTML] Nitric oxide-dependent generation of reactive species in sickle cell disease: actin tyrosine nitration induces defective cytoskeletal polymerization
M Aslan, TM Ryan, TM Townes, L Coward… - Journal of Biological …, 2003 - ASBMB
The intermittent vascular occlusion occurring in sickle cell disease (SCD) leads to ischemia-
reperfusion injury and activation of inflammatory processes including enhanced production
of reactive oxygen species and increased expression of inducible nitric-oxide synthase
(NOS2). Appreciating that impaired nitric oxide-dependent vascular function and the
concomitant formation of oxidizing and nitrating species occur in concert with increased
rates of tissue reactive oxygen species production, liver and kidney NOS2 expression, tissue …
reperfusion injury and activation of inflammatory processes including enhanced production
of reactive oxygen species and increased expression of inducible nitric-oxide synthase
(NOS2). Appreciating that impaired nitric oxide-dependent vascular function and the
concomitant formation of oxidizing and nitrating species occur in concert with increased
rates of tissue reactive oxygen species production, liver and kidney NOS2 expression, tissue …