Cutting Edge: HIV-1 infection induces a selective reduction in STAT5 protein expression

F Pericle, LA Pinto, S Hicks, RA Kirken… - The Journal of …, 1998 - journals.aai.org
F Pericle, LA Pinto, S Hicks, RA Kirken, G Sconocchia, J Rusnak, MJ Dolan, GM Shearer…
The Journal of Immunology, 1998journals.aai.org
HIV-1 infection is accompanied by qualitative and quantitative defects in CD4+ T
lymphocytes. Loss of immune function in HIV patients is usually associated with a profound
dysregulation of cytokine production. To investigate whether cytokine signaling defects
occur during HIV infection, PHA blasts from healthy human donors were infected with two
strains of HIV-1 and screened for the expression of STAT proteins used in cytokine
signaling. A selective decrease in STAT5B was seen 8 days after infection with the BZ167 …
Abstract
HIV-1 infection is accompanied by qualitative and quantitative defects in CD4+ T lymphocytes. Loss of immune function in HIV patients is usually associated with a profound dysregulation of cytokine production. To investigate whether cytokine signaling defects occur during HIV infection, PHA blasts from healthy human donors were infected with two strains of HIV-1 and screened for the expression of STAT proteins used in cytokine signaling. A selective decrease in STAT5B was seen 8 days after infection with the BZ167 dual-tropic HIV isolate, but not with the Ba-L, M-tropic strain. Based on these findings, purified T cells from HIV-infected patients in different stages of disease were also tested for STAT expression; decreases in STAT5A, STAT5B, and STAT1α were observed in all patients. The reduction in STATs seen in vivo and in vitro after HIV infection may contribute to the loss of T cell function in HIV disease.
journals.aai.org