Leptin, the long-sought satiety factor of adipocytes origin, has emerged as one of the major
signals that relay the status of fat stores to the hypothalamus and plays a significant role in
energy homeostasis. Understanding the mechanisms of leptin signaling in the
hypothalamus during normal and pathological conditions, such as obesity, has been the
subject of intensive research during the last decade. It is now established that leptin action in
the hypothalamus in regulation of food intake and body weight is mediated by a neural …