Renal hypertrophy and extracellular matrix accumulation are early features of diabetic
nephropathy. We investigated the role of the NAD (P) H oxidase Nox4 in generation of
reactive oxygen species (ROS), hypertrophy, and fibronectin expression in a rat model of
type 1 diabetes induced by streptozotocin. Phosphorothioated antisense (AS) or sense
oligonucleotides for Nox4 were administered for 2 weeks with an osmotic minipump 72 h
after streptozotocin treatment. Nox4 protein expression was increased in diabetic kidney …