[HTML][HTML] Closely related mammals have distinct asialoglycoprotein receptor carbohydrate specificities
EI Park, JU Baenziger - Journal of Biological Chemistry, 2004 - ASBMB
We recently reported that the rat asialoglycoprotein receptor binds oligosaccharides
terminating with sialic acid (Sia) α2, 6GalNAc. Despite a high percentage of identical amino
acids in their sequences, orthologues of the asialoglycoprotein receptor (ASGP-R) in
different mammals differ in their specificity for terminal Siaα2, 6GalNAc. The recombinant
subunit 1 of the ASGP-R from the rat (RHL-1 or rat hepatic lectin) and the mouse (MHL-1 or
mouse hepatic lectin), which differ at only 12 positions in the amino acid sequence of their …
terminating with sialic acid (Sia) α2, 6GalNAc. Despite a high percentage of identical amino
acids in their sequences, orthologues of the asialoglycoprotein receptor (ASGP-R) in
different mammals differ in their specificity for terminal Siaα2, 6GalNAc. The recombinant
subunit 1 of the ASGP-R from the rat (RHL-1 or rat hepatic lectin) and the mouse (MHL-1 or
mouse hepatic lectin), which differ at only 12 positions in the amino acid sequence of their …