Evaluation of the In Vivo Activity of Tribendimidine against Schistosoma mansoni, Fasciola hepatica, Clonorchis sinensis, and Opisthorchis viverrini
J Keiser, X Shu-Hua, J Chollet, M Tanner… - Antimicrobial agents …, 2007 - Am Soc Microbiol
J Keiser, X Shu-Hua, J Chollet, M Tanner, J Utzinger
Antimicrobial agents and chemotherapy, 2007•Am Soc MicrobiolWe examined the in vivo activity of tribendimidine against selected trematodes. A single 150-
mg/kg dose of tribendimidine achieved a 99.1% reduction of Clonorchis sinensis in rats. A
400-mg/kg dose of tribendimidine reduced Opisthorchis viverrini in hamsters by 95.7%. High
doses of tribendimidine showed no activity against Schistosoma mansoni and Fasciola
hepatica.
mg/kg dose of tribendimidine achieved a 99.1% reduction of Clonorchis sinensis in rats. A
400-mg/kg dose of tribendimidine reduced Opisthorchis viverrini in hamsters by 95.7%. High
doses of tribendimidine showed no activity against Schistosoma mansoni and Fasciola
hepatica.
Abstract
We examined the in vivo activity of tribendimidine against selected trematodes. A single 150-mg/kg dose of tribendimidine achieved a 99.1% reduction of Clonorchis sinensis in rats. A 400-mg/kg dose of tribendimidine reduced Opisthorchis viverrini in hamsters by 95.7%. High doses of tribendimidine showed no activity against Schistosoma mansoni and Fasciola hepatica.
American Society for Microbiology