[HTML][HTML] Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road
MM Levine, KL Kotloff, EM Barry, MF Pasetti… - Nature Reviews …, 2007 - nature.com
MM Levine, KL Kotloff, EM Barry, MF Pasetti, MB Sztein
Nature Reviews Microbiology, 2007•nature.comMore than 50 years of research has yielded numerous Shigella vaccine candidates that
have exemplified both the promise of vaccine-induced prevention of shigellosis and the
impediments to developing a safe and effective vaccine for widespread use, a goal that has
yet to be attained. This Review discusses the most advanced strategies for Shigella vaccine
development, the immune responses that are elicited following disease or vaccination, the
factors that have accelerated or impeded Shigella vaccine development and our ideas for …
have exemplified both the promise of vaccine-induced prevention of shigellosis and the
impediments to developing a safe and effective vaccine for widespread use, a goal that has
yet to be attained. This Review discusses the most advanced strategies for Shigella vaccine
development, the immune responses that are elicited following disease or vaccination, the
factors that have accelerated or impeded Shigella vaccine development and our ideas for …
Abstract
More than 50 years of research has yielded numerous Shigella vaccine candidates that have exemplified both the promise of vaccine-induced prevention of shigellosis and the impediments to developing a safe and effective vaccine for widespread use, a goal that has yet to be attained. This Review discusses the most advanced strategies for Shigella vaccine development, the immune responses that are elicited following disease or vaccination, the factors that have accelerated or impeded Shigella vaccine development and our ideas for the way forward.
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