Structure, function, and biogenesis of the cell wall of Mycobacterium tuberculosis

PJ Brennan - Tuberculosis, 2003 - Elsevier
Much of the early structural definition of the cell wall of Mycobacterium spp. was initiated in
the 1960s and 1970s. There was a long period of inactivity, but more recent developments in
NMR and mass spectral analysis and definition of the M. tuberculosis genome have resulted
in a thorough understanding, not only of the structure of the mycobacterial cell wall and its
lipids but also the basic genetics and biosynthesis. Our understanding nowadays of cell-wall
architecture amounts to a massive “core” comprised of peptidoglycan covalently attached via …