The DOTS strategy for controlling the global tuberculosis epidemic

TR Frieden, SS Munsiff - Clinics in chest medicine, 2005 - chestmed.theclinics.com
In 1997, the Director General of the World Health Organization (WHO) called the directly
observed treatment, short-course (DOTS) strategy ''the most important health breakthrough
of the decade in terms of the number of lives it will save''[1]. DOTS is nothing new; Karel
Styblo developed the essential principles of DOTS in the 1980s [1a]. The five principles of
the WHO-recommended DOTS strategy [2] are: