Manipulation of regulatory T‐cell number and function with CD28‐specific monoclonal antibodies
T Hünig - Advances in immunology, 2007 - Elsevier
Suppressor or “regulatory” CD4 T cells play a key role in the control of autoimmunity and
overshooting immune responses to foreign antigens, but can also obstruct effective
anticancer therapies. The homeostasis and activation of these regulatory T cells (Treg cells)
is tightly connected to that of effector CD4 T cells via the costimulatory receptor CD28 and
the cytokine IL‐2: Both subsets require costimulation to be activated by antigen, and Treg
cells additionally depend on IL‐2 produced by effector CD4 T cells in a costimulation …
overshooting immune responses to foreign antigens, but can also obstruct effective
anticancer therapies. The homeostasis and activation of these regulatory T cells (Treg cells)
is tightly connected to that of effector CD4 T cells via the costimulatory receptor CD28 and
the cytokine IL‐2: Both subsets require costimulation to be activated by antigen, and Treg
cells additionally depend on IL‐2 produced by effector CD4 T cells in a costimulation …