Interleukin (IL)-12 and IL-23 are key cytokines for immunity against Salmonella in humans

C MacLennan, C Fieschi, DA Lammas… - The Journal of …, 2004 - academic.oup.com
C MacLennan, C Fieschi, DA Lammas, C Picard, SE Dorman, O Sanal, JM MacLennan…
The Journal of infectious diseases, 2004academic.oup.com
Patients with inherited deficiency of the interleukin (IL)-12/IL-23-interferon (IFN)-γ axis show
increased susceptibility to invasive disease caused by the intramacrophage pathogens
salmonellae and mycobacteria. We analyzed data on 154 patients with such deficiency.
Significantly more patients with IL-12/IL-23-component deficiency had a history of
salmonella disease than did those with IFN-γ-component deficiency. Salmonella disease
was typically severe, extraintestinal, and caused by nontyphoidal serovars. These findings …
Abstract
Patients with inherited deficiency of the interleukin (IL)-12/IL-23-interferon (IFN)-γ axis show increased susceptibility to invasive disease caused by the intramacrophage pathogens salmonellae and mycobacteria. We analyzed data on 154 patients with such deficiency. Significantly more patients with IL-12/IL-23-component deficiency had a history of salmonella disease than did those with IFN-γ-component deficiency. Salmonella disease was typically severe, extraintestinal, and caused by nontyphoidal serovars. These findings strongly suggest that IL-12/IL-23 is a key cytokine for immunity against salmonella in humans and that IL-12/IL-23 mediates this protective effect partly through IFN-γ-independent pathways. Investigation of the IL-12/IL-23-IFN-γ axis should be considered in patients with invasive salmonella disease.
Oxford University Press