Male development of chromosomally female mice transgenic for Sry
P Koopman, J Gubbay, N Vivian, P Goodfellow… - Nature, 1991 - nature.com
Nature, 1991•nature.com
The initiation of male development in mammals requires one or more genes on the Y
chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many
of the genetic and biological properties expected of a Y-located testis-determining gene. It is
now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis
differentiation and subsequent male development when introduced into chromosomally
female mouse embryos.
chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many
of the genetic and biological properties expected of a Y-located testis-determining gene. It is
now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis
differentiation and subsequent male development when introduced into chromosomally
female mouse embryos.
Abstract
The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.
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