Generation of cloned transgenic pigs rich in omega-3 fatty acids
L Lai, JX Kang, R Li, J Wang, WT Witt, HY Yong… - Nature …, 2006 - nature.com
L Lai, JX Kang, R Li, J Wang, WT Witt, HY Yong, Y Hao, DM Wax, CN Murphy, A Rieke…
Nature biotechnology, 2006•nature.comMeat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human
health. We describe the generation of cloned pigs that express a humanized Caenorhabditis
elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs
produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly
reduced ratio of n-6/n-3 fatty acids (P< 0.001).
health. We describe the generation of cloned pigs that express a humanized Caenorhabditis
elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs
produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly
reduced ratio of n-6/n-3 fatty acids (P< 0.001).
Abstract
Meat products are generally low in omega-3 (n-3) fatty acids, which are beneficial to human health. We describe the generation of cloned pigs that express a humanized Caenorhabditis elegans gene, fat-1, encoding an n-3 fatty acid desaturase. The hfat-1 transgenic pigs produce high levels of n-3 fatty acids from n-6 analogs, and their tissues have a significantly reduced ratio of n-6/n-3 fatty acids (P < 0.001).
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