The choice of adeno-associated virus serotypes for clinical applications is influenced by the
animal model and model system used to evaluate various serotypes. In the present study,
we sought to compare the biologic properties of rAAV2/1, rAAV2/2, and rAAV2/5
transduction in polarized human airway epithelia using viruses purified by a newly
developed common column chromatography method. Results demonstrated that apical
transduction of human airway epithelia with rAAV2/1 was 100-fold more efficient than …