[HTML][HTML] Identification of common transcriptional regulatory elements in interleukin-17 target genes
Interleukin (IL)-17 is the founding member of a novel family of inflammatory cytokines.
Although produced by T cells, IL-17 activates genes and signals typical of innate immune
mediators such as tumor necrosis factor (TNF)-α and IL-1β. Most IL-17 target genes
characterized to date are cytokines or neutrophil-attractive chemokines. Our recent
microarray studies identified an acute phase response gene, 24p3/lipocalin 2, as a novel IL-
17-induced gene. Here we describe a detailed analysis of the 24p3 promoter. We find that …
Although produced by T cells, IL-17 activates genes and signals typical of innate immune
mediators such as tumor necrosis factor (TNF)-α and IL-1β. Most IL-17 target genes
characterized to date are cytokines or neutrophil-attractive chemokines. Our recent
microarray studies identified an acute phase response gene, 24p3/lipocalin 2, as a novel IL-
17-induced gene. Here we describe a detailed analysis of the 24p3 promoter. We find that …