[HTML][HTML] ATF3 represses 72-kDa type IV collagenase (MMP-2) expression by antagonizing p53-dependent trans-activation of the collagenase promoter
C Yan, H Wang, DD Boyd - Journal of Biological Chemistry, 2002 - ASBMB
The murine homologue of the ATF3 transcription factor increases tumor metastases but,
surprisingly, represses 72-kDa type IV metalloproteinase (MMP-2) expression. The current
study describes a novel mechanism by which ATF3 regulates transcription. Progressive
deletions of the MMP-2 promoter indicated a 38-base pair region (− 1659/− 1622) necessary
for the ATF3-mediated repression. This region lacked CREB/AP-1 motifs but contained a
consensus p53 motif shown previously to regulate MMP-2 expression. The activity of a p53 …
surprisingly, represses 72-kDa type IV metalloproteinase (MMP-2) expression. The current
study describes a novel mechanism by which ATF3 regulates transcription. Progressive
deletions of the MMP-2 promoter indicated a 38-base pair region (− 1659/− 1622) necessary
for the ATF3-mediated repression. This region lacked CREB/AP-1 motifs but contained a
consensus p53 motif shown previously to regulate MMP-2 expression. The activity of a p53 …